2023

Montgomery SE, Long L, Russo SJ, Calipari ES, Nestler EJ, Morel C, Han MH (2023) Mesolimbic neural response dynamics predict future individual alcohol drinking in mice. Biological Psychiatry. In Press.

Zachry JE, Kutlu MG, Yoon HJ, Leonard MZ, Chevee M, Patel DD, Gaidici A, Kondev V, Thibeault KC, Bethi R, Tat JT, Melugin PR, Isiktas AU, Joffe ME, Cai DJ, Conn PJ, Grueter BA, Calipari ES (2023) Accumbal D1 and D2 medium spiny neurons have distinct and valence-independent roles in learning. Neuron. In Press. 

Chevée M, Kim C, Crow JN, Follman EG, Calipari ES (2023) Sensitivity to outcome devaluation in operant tasks is better predicted by food restriction level than reinforcement training schedule in mice. eNeuro. Accepted.

Kutlu MG, Tat J, Christensen BA, Zachry JE, Calipari ES (2023) Dopamine release at the time of a predicted aversive outcome causally controls the trajectory and expression of conditioned behavior. Cell Reports. In Press.

Meckel KR, Simpson SS, Godino A, Peck EG, Sens JP, Leonard MZ, George O, Calipari ES, Hofford RS, Kiraly DD (2023) Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking. Neuropsychopharmacology. In press.

Williford KM, Taylor A, Melchior J, Yoon HJ, Sale E, Bedenbaugh MN, Brown JA, Luchsinger JR, Centanni SW, Patel S, Calipari ES, Simerly RB, Winder DG (2023) BNST PKCdelta neurons are differentially recruited by stress and aversive stimuli and drive anxiety-like behavior. Neuropsychopharmacology. In Press. 

Emerson SD, Chevee M, Mews P, Calipari ES (2023) The transcriptional response to acute cocaine is inverted in male mice with a history of cocaine self-administration and withdrawal throughout the mesocorticolimbic system. Molecular and Cellular Neuroscience. In Press.

Jameson AN, Siemann JK, Melchior J, Calipari ES, McMahon DG, Grueter BA (2023) Photoperiod impacts nucleus accumbens dopamine dynamics in a sex-specific manner. eNeuro. In Press.

2022

Follman E, Chevee M, Kim C, Johnson AR, Tat J, Calipari ES (2022) Task parameters influence operant response variability in mice. Psychopharmacology. In Press.

Brown JA, Peterson N, Centanni SW, Jin AY, Yoon HJ, Cajigas S, Bedenbaugh MN, Luchsinger JR, Patel S, Calipari ES, Simerly RB, Winder DG (2022) An ensemble recruited by α2a-adrenergic receptors is engaged in a stressor-specific manner. Neuropsychopharmacology. In Press.

Kutlu, MG, Zachry JE, Melugin PR, Tat J, Cajigas SA, Isiktas AU, Patel DD, Siciliano CA, Schoenbaum G, Sharpe MJ, Calipari ES. (2022) Dopamine signaling in the nucleus accumbens core mediates latent inhibition. Nature Neuroscience. 25, 1071–1081

Morel C, Montgomery SE, Li L, Durand-de Cuttoli R, Teichman EM, Juarez B, Tzavaras N, Ku SM, Flanigan ME, Cai M, Walsh JJ, Russo SJ, Nestler EJ, Calipari ES, Friedman AK, Han MH. (2022) Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors. Nature Communications. 13, 1532

Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ. (2022) Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons. Neuron. 110(6):1068-1083

Brown JA, Petersen N, Centanni SW, Jin AY, Yoon HJ, Cajigas SA, Bedenbaugh MN, Luchsinger JR, Patel S, Calipari ES, Simerly RB, Winder DG. An ensemble recruited by α2a-adrenergic receptors is engaged in a stressor-specific manner in mice. Neuropsychopharmacology.

Johnson AR, Christensen BA, Kelly SJ, Calipari ES. (2022) The influence of reinforcement schedule on experience-dependent changes in motivation. Journal of the Experimental Analysis of Behavior. 54: 339–341

Wilcox JM, Consoli DC, Paffenroth KC, Spitznagel BD, Calipari ES, Bowman AB, Harrison FE. (2022) Manganese-induced hyperactivity and dopaminergic dysfunction depend on age, sex and YAC128 genotype. Pharmacology, Biochemistry, and Behavior. 213:173337.

2021

López AJ, Johnson AR, Euston TJ, Wilson R, Nolan SO, Brady LJ, Thibeault KC, Kelly SJ, Kondev V, Melugin P, Chuang E, Lam TT, Kiraly DD, Calipari ES. (2021) Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens. Communications Biology. 4, 883

Lopez AJ, Johnson AR, Kunnath AJ, Morris AD, Zachry JE, Thibeault KC, Kutlu MG, Siciliano CA, Calipari ES. (2021) An optimized procedure for robust volitional cocaine intake in mice. Experimental and clinical psychopharmacology. 29(4);319-333

Hofford RS, Euston TJ, Wilson R, Meckel KR, Peck EG, Godino A, Landry JL, Hurd Y, Calipari ES, Lam T, Kiraly DD (2021) Granulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex. Journal of Neuroscience. 41 (7) 1553-1565

Vaillancourt K, Yang J, Chen GG, Yerko V, Théroux JF, Aouabed Z, Lopez AJ, Thibeault KC, Calipari ES, Labonte B, Mechawar N, Ernst C, Nagy C, Forne T, Nestler EJ, Mash D, Turecki G. (2021) Cocaine-related DNA methylation in caudate neurons alters 3D chromatin structure of the IRXA gene cluster. Molecular Psychiatry. 26(7):3134-3151.

2020

Badimon A, Strasburger HJ, Ayata P, Chen X, Nair A, Ikegami A, Hwang P, Chan AT, Graves SM, Uweru OJ, Ledderose C, Kutlu MG, Wheeler MA, Khan A, Ishikawa M, Wang YC, Loh YE, Jiang JX, Surmeier DJ, Robson SC, Junger W, Sebra R, Calipari ES, Kenny PJ, Eyo U, Colonna M, Quintana FJ, Wake H, Gradinaru V, Schaefer A. (2020) Negative feedback control of neuronal activity by microglia. Nature. 586, 417-423

Consoli DC, Brady LJ, Bowman AB, Calipari ES*, Harrison FE* (2020) Ascorbate deficiency decreases dopamine release in gulo–/– and APP/PSEN1 mice. Journal of Neurochemistry. 157(3): 656-665

Liu Y, Juarez B, Montgomery SE, Morel C, Zhang S, Kong Y, Calipari ES, Nestler EJ, Zhang L, Han MH (2020) Different Adaptations of Dopamine Release in Nucleus Accumbens Shell and Core of Individual Alcohol Drinking Groups of Mice. Neuropharmacology. 175:108176

Kutlu MG#, Zachry JE#, Brady LJ, Melugin P, Sanders C, Tat J, Johnson AR, Thibeault KC, Lopez AJ, Siciliano CA, Calipari ES (2020) A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies. Neuropsychopharmacology. 45:1463-1472

Issler O, van der Zee YY, Ramakrishnan A, Wang J, Tan C, Loh YE, Purushothaman I, Walker DM, Lorsch ZS, Hamilton PJ, Peña CJ, Flaherty E, Hartley BJ, Torres-Berrío A, Parise EM, Kronman H, Duffy JE, Estill MS, Calipari ES, Labonté B, Neve RL, Tamminga CA, Brennand KJ, Dong Y, Shen L, Nestler EJ (2020) Sex-specific role for the long non-coding RNA LINC00473 in depression. Neuron. S0896-6273(20)30230-0.

Lepack AE, Werner CT, Farrelly LA, Zhong P, Smith ACW, Thompson RE, Ramakrishnan A, Lyu Y, Syeward AF, Martin JA, Fulton SL, Bastle RM, O’Connor R, Want ZJ, Muir TW, Molina H, Tureky G, Shen L, Yan Z, Calipari ES, Dietz DM, Kenny PJ, Maze I (2020) Dopaminylation of histone H3 in ventral tegmental area regulates cocaine-seeking. Science. 368(6487):197-201.

Flanigan M, Aleyasin H, LeClair K, Lucas EK, Matikainen-Ankney B, Takahashi A, Menard C, Bouchard S, Pfau ML, Golden SA, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ. (2020) Orexin signaling in the lateral habenula encodes the valence of aggressive social encounters. Nature Neuroscience. 23(5):638-650.

2019

Brady LJ, Hofford RS, Tat J, Calipari ES, Kiraly DD. (2019) Granulocyte-colony stimulating factor alters the pharmacodynamic properties of cocaine in female mice. ACS Chemical Neuroscience. In Press.
*Denotes Co-corresponding, Co-last author

Fakira AK, Peck EG, Liu Y, Lueptow LM, Trimbrake NA, Han MH, Calipari ES, Devi LA (2019) The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences. Neuropharmacology. 157:107666.

Calipari ES, Godino A, Salery M, Damez-Werno DM, Cahill ME, Werner CT, Gancarz AM, Peck EG, Jlayer Z, Rabkin J, Landry JA, Smith ACW, Defilippi P, Kenny PJ, Hurd YL, Neve RL, Dietz DM, Nestler EJ (2019) Synaptic microtubule-associated protein EB3 and SRC phosphorylation mediate structural and behavioral adaptations during withdrawal from cocaine self-administration. The Journal of Neuroscience. 39(29)5634-5646

Johnson AR, Thibeault KC, Lopez AJ, Peck EG, Sands LP, Sanders CM, Kutlu MG, Calipari ES (2019) Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement. Neuropsychopharmacology. 44, 1189-1197

2018

Mervosh N, Wilson R, Rauniyar N, Hofford R, Kultu MG, Calipari ES, Lam T, Kiraly DD (2018) Granulocyte-colony stimulating factor alters the proteomic landscape of the ventral tegmental area. Proteomes. In press.

Zhang H, Chaudhury D, Nectow AR, Friedman AK, Zhang S, Juarez B, Liu H, Pfau ML, Aleyasin H, Jiang C, Crumiller M, Calipari ES, Ku SM, Morel C, Tzavaras N, Montgomery SE, He M, Salton SR, Russo SJ, Nestler EJ, Friedman JM, Cao JL, Han MH. Alpha1 and beta3 adrenergic receptor-mediated mesolimbic homeostatic plasticity confers resilience to social stress in susceptible mice. (2018) Biological Psychiatry. In Press.

Kutlu MG, Brady LJ, Peck EG, Hofford RH, Yorganson JT, Siciliano CA, Kiraly DD, Calipari ES. (2018) Granulocyte colony stimulating factor enhances reward learning through potentiation of mesolimbic dopamine system function. J. Neuroscience. In Press.

Ribeiro EA, Salery M, Scarpa JS, Calipari ES, Hamilton PJ, Ku SM, Kronman K, Purushothaman I, Juarez B, Heshmati M, Doyle M, Lardner C, Burek D, Strat AN, Pirpinias S, Mouzon EA, Han MH, Neve R, Bagot RC, Kasarskis A, Koo JW, Nestler EJ. Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine. Nature Communications. 9(1):3149.

Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahil KA,  Lardner CK, Godino A, Kronman H, Rabkin J, Ramakrishnan A, Lorsch ZA, Mews P, Doyle MA, Feng J, Labonte B, Koo JW, Bagot RC, Logan RW, Seney ML, Calipari ES#†, Shen L†, Nestler EJ#†. Cocaine self-administration alters transcriptome-wide responses in the brain’s reward circuitry. Biological Psychiatry. In Press. #Co-corresponding author

Calipari ES, Godino A, Peck EG, Salery M, Mervosh NL, Landry JA, Russo SJ, Hurd YL, Nestler EJ, Kiraly DD.Granulocyte-colony stimulating factor controls neural and behavioral plasticity in response to cocaine. Nat Commun. 2018 Jan 16;9(1):9. 

2017

Juarez B, Morel C, Ku SM, Liu Y, Zhang H, Montgomery S, Gregoire H, Riberio E, Crumiller M, Jackson K, Roman-Ortiz Walsh JJ, Jackson K, Croote D, Zhu Y, Zhang S, Vendruscolo LF, Edwards S, Roberts A, Hodes GE, Yongke Lu, Calipari ES, Chaudhury D, Friedman AK, Han MH (2017) Midbrain circuit regulation of individual alcohol drinking behaviors. Nature Communications. 8:2220.

Barker DJ, Miranda-Barrientos J, Zhang S, Root  DH, Wang HL, Liu B, Calipari ES, Morales M (2017) Lateral preoptic control of the lateral habenula through convergent glutamate and GABA transmission. Cell Reports. 21 (7), 1757–1769.

Siciliano CA, Saha K, Calipari ES, Fordahl SC, Chen R, Khoshbouei H, Jones SR (2017) Amphetamine reverses escalated cocaine intake via restoration of dopamine transporter conformation. Journal of Neuroscience. 2604-17, 

Labonte B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, Scarpa JR, Moy G, Loh YE, Cahill ME, Lorsch ZS, Hamilton PJ, Calipari ES, Hodes GE, Issler O, Kronman H, Pfau M, Obradovic ALJ, Dong Y, Neve RL, Russo S, Kazarskis A, Tamminga C, Mechawar N, Turecki G, Zhang B, Shen L, Nestler EJ (2017) Sex-specific transcriptional signatures in human depression. Nature Medicine. 23, 1102–1111.

Dash S, Balasubramaniam M, Rana T,  Godino A, Peck EG, Goodwin JS, Villalta F, Calipari ES,  Nestler EJ, Dash C, Pandhare J (2017) Poly (ADP-Ribose) Polymerase-1 (PARP-1) Induction by Cocaine Is Post-Transcriptionally Regulated by miR-125b. eNeuro. ENEURO.0089-17.2017.

Muir J, Lorsch ZS, Ramakrishnan C, Deisseroth K, Nestler EJ, Calipari ES, Bagot RC (2017) In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens. Neuropsychopharmacology. 43(2):255-263.

Engmann O, Labonte B, Mitchell A, Bashtrykov P, Calipari ES, Rosenbluh C, Loh EDW, Walker DM, Burek D, Hamilton P, Issler O, Never R, Tureki G, Hurd Y, Chess A, Shen L, Jeltsch A, Akbarian S, Nestler EJ (2017) The largest number of cocaine-induced changes in histone modifications are associated with increased expression and DNA-DNA interactions of Auts2. Biological Psychiatry. 82(11):794-805

Calipari ES, Juarez B, Morel C, Walker DM, Cahill ME, Riberio E, Deisseroth K, Han MH, Nestler EJ. Dopaminergic dynamics underlying sex-specific cocaine reward (2017). Nature Communications. 8:13877.

2016

Kiraly DD, Walker DM, Calipari ES, Labonte B, Issler O, Pena CJ, Ribiero E, Russo SJ, Nester EJ. Host Microbiota serve as an important regulator of behavioral responses to cocaine (2016). Sci. Reports. In Press.

Damez-Werno D, Sun H, Scobie H, Shao NY, Dias C, Rabkin J, Calipari ES, Maze I, Peña CJ, Walker DM, Cahill M, Chandra R, Gancarz A, Mouzon E, Landry JA, Cates H, Lobo MK, Dietz D, Allis C, Guccione E, Turecki G, Defilippi P, Neve R, Hurd Y, Shen L, Nestler EJ (2016). Histone Arginine Methylation in Cocaine Action: Essential Role of Src Signaling in the Nucleus Accumbens. Proceedings of the National Academy of Sciences U.S.A. In Press.

Salvatore MF, Calipari ES, Jones SR. Regulation of tyrosine hydroxylase expression and phosphorylation in dopamine transporter heterozygote and knockout mice (2016). ACS Chem. Neurosci. In Press.

Siciliano CA, Calipari ES, Yorgason JT, Lovinger DM, Mateo Y, Jiminez VA, Grant KA, Jones SR. (2016) Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques (2016). Psychopharmacology. 233(8):1435-43.

Wook Koo J, Labonté B, Engmann O, Calipari ES, Juarez B, Lorsch Z, Walsh JJ, Friedman AK, Yorgason JT, Han MH, Nestler EJ. (2016) Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress-Induced Depressive Behaviors. Biol Psychiatry. Sep 15;80(6):469-478.

Calipari ES, Bagot RC, Purushothaman I, Davidson TJ, Yorgason JT, Peña CJ, Walker DM, Pirpinias ST, Guise KG, Ramakrishnan C, Deisseroth K, Nestler EJ (2016) In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proceedings of the National Academy of Sciences U.S.A. 113(10):2726-31.

Siciliano CA, Calipari ES, Yorgason JT, Cuzon Carlson VC, Helms CM, Lovinger DM, Grant KA, Jones SR. Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. (2015) Drug and Alcohol Dependence. 158:159-63.

Yorgason JT, Calipari ES, Ferris MJ, Weiner JL, Jones SR. (2015) Social Isolation Rearing Increases Dopamine Uptake and Psychostimulant Potency in the Striatum. Neuropharmacology. 101:471-9.

Koo JW, Labonte B, Engmann O, Calipari ES, Juarez B, Lorsche Z, Walsh JJ, Friedman AK, Han MH, Nestler EJ. (2015) Essential role of mesolimbic brain-derived neurotrophic factor in chronic defeat-induced depressive behaviors. Biological Psychiatry. In Press.

Sun H, Calipari ES, Beveridge TJ, Jones SR, Chen R. (2015) The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Neuroscience. 307:253-61. 

Siciliano CA, Calipari ES, Cuzon Carlson VC, Helms CM, Lovinger DM, Grant KA, Jones SR.  (2015) Voluntary Ethanol Intake Predicts Kappa Opioid Receptor Supersensitivity and Regionally Distinct Dopaminergic Adaptations in Macaques. The Journal of Neuroscience. 35(15):5959-68.

Ferris MJ, Calipari ES, Rose JH, Siciliano CA, Sun H, Chen R, Jones SR. (2015) A single amphetamine bolus restores dopamine nerve terminal function and sensitivity to cocaine following a history of cocaine self-administration. Neuropsychopharmacology. 40(8):1826-36.

Calipari ES, Ferris MJ, Siciliano CA, Jones SR. (2015) Differential influence of dopamine transport rate on the potencies of cocaine amphetamine and methylphenidate. ACS Chemical Neuroscience. 6(1):155-62.

Calipari ES, Siciliano CA, Zimmer BA, Jones SR. (2015). Brief intermittent cocaine self-administration and abstinence sensitizes cocaine effects on the dopamine transporter and increases drug seeking. Neuropsychopharmacology.40(3):728-35.

Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez‐Werno D, Scobie K, Bagot R, LaBonte B, Ribeiro E, Liu XC, Kennedy P, Vialou V, Ferguson D, Pena CJ, Calipari ES, Koo J, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ. (2014) β-Catenin Mediates the Development of Behavioral Resilience. Nature. 516(7529):51-5.

Siciliano CA, Calipari ES, Jones SR. (2014) Amphetamine potency varies across striatal subregions with dopamine uptake rate.  The Journal of Neurochemistry. 131(3): 348-55.

Siciliano CA, Calipari ES, Ferris MJ, Jones SR. (2014) Biphasic Mechanisms of Amphetamine Action at the Dopamine Terminal. The Journal of Neuroscience. 34(16): 5575-82.

Calipari ES, Ferris MJ, Siciliano CA, Jones SR. (2014) Intermittent cocaine self-administration produces sensitization of stimulant effects at the dopamine transporter. Journal of Pharmacology and Experimental Therapeutics. 349(2): 192-8.

Calipari ES, Jones SR. (2014) Sensitized nucleus accumbens dopamine terminal responses to methylphenidate and dopamine transporter releasers after intermittent-access self-administration.Neuropharmacology. 82:1-10.

Calipari ES, Sun H, Eldeeb K, Feng X, Howlett AC, Jones SR, Chen R. (2014) Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology. 39(8): 1833-42.

Calipari ES, Ferris MJ, Melchior JR, Bermejo K, Salahpour A, Roberts DC, Jones SR. (2014) Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations. Addiction Biology. 19(2):145-55.

Rose JH, Calipari ES, Mathews TA, Jones SR. (2013) Greater ethanol-induced locomotor activation in DBA/2J versus C57BL/6J mice is not predicted by presynaptic striatal dopamine dynamics. PLOS ONE. 8(12):e83852. 

Calipari ES, Ferris MJ, Caron MG, Roberts DC, Jones SR. (2013) Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression. Nature Communications. 4:2720.

Calipari ES, Ferris MJ, Roberts DCS, Jones SR. (2013) Extended Access of Cocaine Self-Administration Results in Tolerance to the Dopamine-Elevating and Locomotor-Stimulating Effects of Cocaine. The Journal of Neurochemistry. 128(2):224-32.

Calipari ES, Beveridge TJ, Jones SR, Porrino LJ. (2013) Withdrawal from extended-access cocaine self-administration results in dysregulated functional activity and altered locomotor activity in rats. European Journal of Neuroscience. 38(12):3749-57.  *Figure 5 selected for journal front cover illustration.

Calipari ES, Ferris MJ, Zimmer BA, Roberts DCS, Jones SR.  (2013) Temporal pattern of cocaine intake determines tolerance versus sensitization of cocaine effects at the dopamine transporter. Neuropsychopharmacology. 38(12):2385-92.

Ferris MJ, Calipari ES, Melchior JR, España RE, Jones SR. (2013) Paradoxical tolerance to cocaine after initial supersensitivity in drug use prone animals. European Journal of Neuroscience. 38(4):2628-36.

Calipari ES, Huggins KN, Matthews T, Jones SR. Conserved dorsal-ventral gradient of dopamine release and uptake rate in mice, rats and rhesus macaques. (2012) Neurochemistry International. 61(7):986-91.

Ferris MJ, Calipari ES, Melchior JR, Roberts DC, Jones SR. (2012). Cocaine self-administration produces pharmacological tolerance: Differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology, 37(7): 1708-1716.  *Figure 1 selected for journal front cover illustration.